#Created on Dec 18, 2006 begin parameters 1 Avogadros_number=6.0221415*10^23 2 Cell_tot_conc=1 3 Cell_volume=40e-15 4 Dig1_num=1460 5 Dig1_tot_conc=Dig1_num*1e6/(Cell_volume*Avogadros_number) 6 Dig2_num=1310 7 Dig2_tot_conc=Dig2_num*1e6/(Cell_volume*Avogadros_number) 8 Far1_num=238 9 Far1_tot_conc=Far1_num*1e6/(Cell_volume*Avogadros_number) 10 Fus3_Kss1_Kd_preference_factor=10 11 Fus3_Kss1_preference_PO4_factor= 12 Fus3_num=8480 13 Fus3_tot_conc=Fus3_num*1e6/(Cell_volume*Avogadros_number) 14 GTP_modulating_factor= 15 Gpa1_num=9000 16 Gpa1_tot_conc=Gpa1_num*1e6/(Cell_volume*Avogadros_number) 17 kcat_Fus3pT_Dig1_PO4=kcat_Fus3pTpY_Dig1_PO4/MAPK_pT_only_PO4_factor 18 kcat_Fus3pT_Dig2_PO4=kcat_Fus3pTpY_Dig2_PO4/MAPK_pT_only_PO4_factor 19 kcat_Fus3pT_Far1_PO4=kcat_Fus3pTpY_Far1_PO4/MAPK_pT_only_PO4_factor 20 kcat_Fus3pTpY_Dig1_PO4= 21 kcat_Fus3pTpY_Dig2_PO4= 22 kcat_Fus3pTpY_Far1_PO4= 23 kcat_Fus3pY_Dig1_PO4=kcat_Fus3pTpY_Dig1_PO4/MAPK_pY_only_PO4_factor 24 kcat_Fus3pY_Dig2_PO4=kcat_Fus3pTpY_Dig2_PO4/MAPK_pY_only_PO4_factor 25 kcat_Fus3pY_Far1_PO4=kcat_Fus3pTpY_Far1_PO4/MAPK_pY_only_PO4_factor 26 kcat_Gpa1GDP_GTP=6.17*10^(-4) 27 kcat_Gpa1GDPSte4Ste18_GTP=kcat_Gpa1GDP_GTP/GTP_modulating_factor 28 kcat_Gpa1GTP_GDP=5*10^(-3) 29 kcat_Kss1pT_Dig1_PO4=kcat_Kss1pTpY_Dig1_PO4/MAPK_pT_only_PO4_factor 30 kcat_Kss1pT_Dig2_PO4=kcat_Kss1pTpY_Dig2_PO4/MAPK_pT_only_PO4_factor 31 kcat_Kss1pT_Far1_PO4=kcat_Kss1pTpY_Far1_PO4/MAPK_pT_only_PO4_factor 32 kcat_Kss1pTpY_Dig1_PO4=kcat_Fus3pTpY_Dig1_PO4 33 kcat_Kss1pTpY_Dig2_PO4=kcat_Fus3pTpY_Dig2_PO4 34 kcat_Kss1pTpY_Far1_PO4=kcat_Fus3pTpY_Far1_PO4 35 kcat_Kss1pY_Dig1_PO4=kcat_Kss1pTpY_Dig1_PO4/MAPK_pY_only_PO4_factor 36 kcat_Kss1pY_Dig2_PO4=kcat_Kss1pTpY_Dig2_PO4/MAPK_pY_only_PO4_factor 37 kcat_Kss1pY_Far1_PO4=kcat_Kss1pTpY_Far1_PO4/MAPK_pY_only_PO4_factor 38 kcat_MAPKpT_Sst2_PO4=MAPK_pT_only_PO4_factor*kcat_MAPKpTpY_Sst2_PO4 39 kcat_MAPKpT_Ste11_PO4=MAPK_pT_only_PO4_factor*kcat_MAPKpTpY_Ste11_PO4 40 kcat_MAPKpTpY_Sst2_PO4= 41 kcat_MAPKpTpY_Ste11_PO4= 42 kcat_MAPKpY_Sst2_PO4=MAPK_pY_only_PO4_factor*kcat_MAPKpTpY_Sst2_PO4 43 kcat_MAPKpY_Ste11_PO4=MAPK_pY_only_PO4_factor*kcat_MAPKpTpY_Ste11_PO4 44 kcat_Msg5_MAPK_PO4=0.08 45 kcat_PheromoneSte2Gpa1GDP_GTP=GTP_modulating_factor*kcat_PheromoneSte2Gpa1GDPSte4Ste18_GTP 46 kcat_PheromoneSte2Gpa1GDPSte4Ste18_GTP=1.5 47 kcat_Ptp_MAPK_PO4= 48 kcat_Sst2Gpa1GTP_GDP=4 49 kcat_Ste11pSSte5Ste5Ste7_pS=kcat_Ste11pSpSpTSte5Ste5Ste7_pS/Ste11_pS_only_PO4_factor 50 kcat_Ste11pSSte5Ste5Ste7pS_pT=kcat_Ste11pSpSpTSte5Ste5Ste7pS_pT/Ste11_pS_only_PO4_factor 51 kcat_Ste11pSpSSte5Ste5Ste7_pS=kcat_Ste11pSpSpTSte5Ste5Ste7_pS 52 kcat_Ste11pSpSSte5Ste5Ste7pS_pT=kcat_Ste11pSpSpTSte5Ste5Ste7pS_pT 53 kcat_Ste11pSpSpTSte5Ste5Ste7_pS= 54 kcat_Ste11pSpSpTSte5Ste5Ste7pS_pT= 55 kcat_Ste20Ste4Ste18Ste5Ste11_pS= 56 kcat_Ste20Ste4Ste18Ste5Ste11pS_pS=kcat_Ste20Ste4Ste18Ste5Ste11_pS 57 kcat_Ste20Ste4Ste18Ste5Ste11pSpS_pT=kcat_Ste20Ste4Ste18Ste5Ste11_pS 58 kcat_Ste5Ste7pSFus3_pT=kcat_Ste5Ste7pSpTFus3_pT/Ste7_pS_only_PO4_factor 59 kcat_Ste5Ste7pSFus3_pY=kcat_Ste5Ste7pSpTFus3_pY/Ste7_pS_only_PO4_factor 60 kcat_Ste5Ste7pSFus3pT_pY=kcat_Ste5Ste7pSpTFus3pT_pY/Ste7_pS_only_PO4_factor 61 kcat_Ste5Ste7pSFus3pY_pT=kcat_Ste5Ste7pSpTFus3pY_pT/Ste7_pS_only_PO4_factor 62 kcat_Ste5Ste7pSpTFus3_pT=0.008 63 kcat_Ste5Ste7pSpTFus3_pY=1 64 kcat_Ste5Ste7pSpTFus3pT_pY=0.45 65 kcat_Ste5Ste7pSpTFus3pY_pT=0.007 66 kcat_Ste7pSKss1_pT=kcat_Ste7pSpTKss1_pT/Ste7_pS_only_PO4_factor 67 kcat_Ste7pSKss1_pY=kcat_Ste7pSpTKss1_pY/Ste7_pS_only_PO4_factor 68 kcat_Ste7pSKss1pT_pY=kcat_Ste7pSpTKss1pT_pY/Ste7_pS_only_PO4_factor 69 kcat_Ste7pSKss1pY_pT=kcat_Ste7pSpTKss1pY_pT/Ste7_pS_only_PO4_factor 70 kcat_Ste7pSpTKss1_pT=Fus3_Kss1_preference_PO4_factor*kcat_Ste5Ste7pSpTFus3_pT 71 kcat_Ste7pSpTKss1_pY=Fus3_Kss1_preference_PO4_factor*kcat_Ste5Ste7pSpTFus3_pY 72 kcat_Ste7pSpTKss1pT_pY=Fus3_Kss1_preference_PO4_factor*kcat_Ste5Ste7pSpTFus3pT_pY 73 kcat_Ste7pSpTKss1pY_pT=Fus3_Kss1_preference_PO4_factor*kcat_Ste5Ste7pSpTFus3pY_pT 74 kcat_YckPheromoneSte2_PO4=1*10^(-1) 75 kcat_YckSte2_PO4=7.4*10^(-4) 76 kcat_nonspecific_dephosph= 77 Kd_Fus3pTpY_Dig1=0.75 78 Kd_Fus3pTpY_Dig2=0.25 79 Kd_Fus3pTpY_Far1=1.75 80 Kd_Kss1pTpY_Dig1=13 81 Kd_Kss1pTpY_Dig2=4.3 82 Kd_Kss1pTpY_Far1=12 83 Kd_Msg5_MAPK=1.4 84 Kd_Pheromone_Ste2=4.9*10^(-3) 85 Kd_Ste5_Fus3=1 86 Kd_Ste5_Kss1=6.5 87 Kd_Ste7_MAPK=0.1 88 kdeg_Gpa1=1.93*10^(-4) 89 kdeg_Sst2=3*10^(-4) 90 kdeg_Sst2_PO4=5.8*10^(-4) 91 kdeg_Ste11=5.8*10^(-5) 92 kdeg_Ste11_PO4=2.3*10^(-4) 93 kdeg_Ste2_PO4=3.2*10^(-3) 94 kdeg_Ste7= 95 kdeg_Ste7pSpT=4.6*10^(-4) 96 kdilution=1.28*10^(-4) 97 kdilutionsynth_Dig1=Dig1_tot_conc*kdilution 98 kdilutionsynth_Dig2=Dig2_tot_conc*kdilution 99 kdilutionsynth_Far1=Far1_tot_conc*kdilution 100 kdilutionsynth_Fus3=Fus3_tot_conc*kdilution 101 kdilutionsynth_Gpa1=Gpa1_tot_conc*kdilution 102 kdilutionsynth_Kss1=Kss1_tot_conc*kdilution 103 kdilutionsynth_Msg5=Msg5_tot_conc*kdilution 104 kdilutionsynth_Ptp=Ptp_tot_conc*kdilution 105 kdilutionsynth_Sst2=Sst2_tot_conc*kdilution 106 kdilutionsynth_Ste11=Ste11_tot_conc*kdilution 107 kdilutionsynth_Ste12=Ste12_tot_conc*kdilution 108 kdilutionsynth_Ste2=Ste2_tot_conc*kdilution 109 kdilutionsynth_Ste20=Ste20_tot_conc*kdilution 110 kdilutionsynth_Ste4Ste18=Ste4_tot_conc*kdilution 111 kdilutionsynth_Ste5=Ste5_tot_conc*kdilution 112 kdilutionsynth_Ste7=Ste7_tot_conc*kdilution 113 kdilutionsynth_Yck=Yck_tot_conc*kdilution 114 kdilutionsynth_pheromone=Pheromone_tot_conc*kdilution 115 kinternalization_Ste2=2.9*10^(-4) 116 Km_synth_Ste12_Dig2= 117 Km_synth_Ste12_Far1= 118 Km_synth_Ste12_Fus3= 119 Km_synth_Ste12_Gpa1= 120 Km_synth_Ste12_Msg5= 121 Km_synth_Ste12_Ptp= 122 Km_synth_Ste12_Sst2= 123 Km_synth_Ste12_Ste12= 124 Km_synth_Ste12_Ste2= 125 koff_Fus3pT_Dig1=MAPK_pT_only_Kd_factor*koff_Fus3pTpY_Dig1 126 koff_Fus3pT_Dig2=MAPK_pT_only_Kd_factor*koff_Fus3pTpY_Dig2 127 koff_Fus3pT_Far1=MAPK_pT_only_Kd_factor*koff_Fus3pTpY_Far1 128 koff_Fus3pTpY_Dig1=kon_Fus3pTpY_Dig1*Kd_Fus3pTpY_Dig1 129 koff_Fus3pTpY_Dig2=kon_Fus3pTpY_Dig2*Kd_Fus3pTpY_Dig2 130 koff_Fus3pTpY_Far1=kon_Fus3pTpY_Far1*Kd_Fus3pTpY_Far1 131 koff_Fus3pY_Dig1=MAPK_pY_only_Kd_factor*koff_Fus3pTpY_Dig1 132 koff_Fus3pY_Dig2=MAPK_pY_only_Kd_factor*koff_Fus3pTpY_Dig2 133 koff_Fus3pY_Far1=MAPK_pY_only_Kd_factor*koff_Fus3pTpY_Far1 134 koff_Gpa1GDP_Ste4Ste18= 135 koff_Gpa1GTP_Ste4Ste18=GTP_modulating_factor*koff_Gpa1GDP_Ste4Ste18 136 koff_Kss1pT_Dig1=MAPK_pT_only_Kd_factor*koff_Kss1pTpY_Dig1 137 koff_Kss1pT_Dig2=MAPK_pT_only_Kd_factor*koff_Kss1pTpY_Dig2 138 koff_Kss1pT_Far1=MAPK_pT_only_Kd_factor*koff_Kss1pTpY_Far1 139 koff_Kss1pTpY_Dig1=kon_Kss1pTpY_Dig1*Kd_Kss1pTpY_Dig1 140 koff_Kss1pTpY_Dig2=kon_Kss1pTpY_Dig2*Kd_Kss1pTpY_Dig2 141 koff_Kss1pTpY_Far1=kon_Kss1pTpY_Far1*Kd_Kss1pTpY_Far1 142 koff_Kss1pY_Dig1=MAPK_pY_only_Kd_factor*koff_Kss1pTpY_Dig1 143 koff_Kss1pY_Dig2=MAPK_pY_only_Kd_factor*koff_Kss1pTpY_Dig2 144 koff_Kss1pY_Far1=MAPK_pY_only_Kd_factor*koff_Kss1pTpY_Far1 145 koff_MAPKpT_Sst2=MAPK_pT_only_Kd_factor*koff_MAPKpTpY_Sst2 146 koff_MAPKpT_Ste11=MAPK_pT_only_Kd_factor*koff_MAPKpTpY_Ste11 147 koff_MAPKpTpY_Sst2= 148 koff_MAPKpTpY_Ste11= 149 koff_MAPKpY_Sst2=MAPK_pY_only_Kd_factor*koff_MAPKpTpY_Sst2 150 koff_MAPKpY_Ste11=MAPK_pY_only_Kd_factor*koff_MAPKpTpY_Ste11 151 koff_Msg5_MAPK=kon_Msg5_MAPK*Kd_Msg5_MAPK 152 koff_Pheromone_Ste2=1.0*10^(-3) 153 koff_Ptp_MAPK= 154 koff_Ste12_Dig1= 155 koff_Ste12_Dig1PO4=Ste12_Dig1_PO4_factor*koff_Ste12_Dig1 156 koff_Ste12_Dig2= 157 koff_Ste12_Dig2PO4=Ste12_Dig2_PO4_factor*koff_Ste12_Dig2 158 koff_Ste12_Fus3= 159 koff_Ste12_Fus3pT=Ste12_Fus3_pT_factor*koff_Ste12_Fus3 160 koff_Ste12_Fus3pTpY=Ste12_Fus3_pTpY_factor*koff_Ste12_Fus3 161 koff_Ste12_Fus3pY=Ste12_Fus3_pY_factor*koff_Ste12_Fus3 162 koff_Ste12_Kss1= 163 koff_Ste12_Kss1pT=Ste12_Kss1_pT_factor*koff_Ste12_Kss1 164 koff_Ste12_Kss1pTpY=Ste12_Kss1_pTpY_factor*koff_Ste12_Kss1 165 koff_Ste12_Kss1pY=Ste12_Kss1_pY_factor*koff_Ste12_Kss1 166 koff_Ste12Dig1_Dig2=koff_Ste12_Dig2/Ste12_Dig1_Dig2_coop_factor 167 koff_Ste12Dig1_Dig2PO4=Ste12_Dig2_PO4_factor*koff_Ste12_Dig2/Ste12_Dig1_Dig2_coop_factor 168 koff_Ste12Dig1_Fus3=koff_Ste12_Fus3/Ste12_Dig1_Fus3_coop_factor 169 koff_Ste12Dig1_Fus3pT=Ste12_Fus3_pT_factor*koff_Ste12_Fus3/Ste12_Dig1_Fus3_coop_factor 170 koff_Ste12Dig1_Fus3pTpY=Ste12_Fus3_pTpY_factor*koff_Ste12_Fus3/Ste12_Dig1_Fus3_coop_factor 171 koff_Ste12Dig1_Fus3pY=Ste12_Fus3_pY_factor*koff_Ste12_Fus3/Ste12_Dig1_Fus3_coop_factor 172 koff_Ste12Dig1_Kss1=koff_Ste12_Kss1/Ste12_Dig1_Kss1_coop_factor 173 koff_Ste12Dig1_Kss1pT=Ste12_Kss1_pT_factor*koff_Ste12_Kss1/Ste12_Dig1_Kss1_coop_factor 174 koff_Ste12Dig1_Kss1pTpY=Ste12_Kss1_pTpY_factor*koff_Ste12_Kss1/Ste12_Dig1_Kss1_coop_factor 175 koff_Ste12Dig1_Kss1pY=Ste12_Kss1_pY_factor*koff_Ste12_Kss1/Ste12_Dig1_Kss1_coop_factor 176 koff_Ste12Dig2_Dig1=koff_Ste12_Dig1/Ste12_Dig1_Dig2_coop_factor 177 koff_Ste12Dig2_Dig1PO4=Ste12_Dig1_PO4_factor*koff_Ste12_Dig1/Ste12_Dig1_Dig2_coop_factor 178 koff_Ste12Fus3_Dig1=koff_Ste12_Dig1/Ste12_Dig1_Fus3_coop_factor 179 koff_Ste12Fus3_Dig1PO4=Ste12_Dig1_PO4_factor*koff_Ste12_Dig1/Ste12_Dig1_Fus3_coop_factor 180 koff_Ste12Fus3Dig2_Dig1=koff_Ste12_Dig1/(Ste12_Dig1_Dig2_coop_factor*Ste12_Dig1_Fus3_coop_factor) 181 koff_Ste12Fus3Dig2_Dig1PO4=Ste12_Dig1_PO4_factor*koff_Ste12_Dig1/(Ste12_Dig1_Dig2_coop_factor*Ste12_Dig1_Fus3_coop_factor) 182 koff_Ste12Kss1_Dig1=koff_Ste12_Dig1/Ste12_Dig1_Kss1_coop_factor 183 koff_Ste12Kss1_Dig1PO4=Ste12_Dig1_PO4_factor*koff_Ste12_Dig1/Ste12_Dig1_Kss1_coop_factor 184 koff_Ste12Kss1Dig2_Dig1=koff_Ste12_Dig1/(Ste12_Dig1_Dig2_coop_factor*Ste12_Dig1_Kss1_coop_factor) 185 koff_Ste12Kss1Dig2_Dig1PO4=Ste12_Dig1_PO4_factor*koff_Ste12_Dig1/(Ste12_Dig1_Dig2_coop_factor*Ste12_Dig1_Kss1_coop_factor) 186 koff_Ste2_Gpa1= 187 koff_Ste2_Gpa1Ste4Ste18=koff_Ste2_Gpa1/Ste2_Gpa1_Ste4Ste18_coop_factor 188 koff_Ste2_Sst2= 189 koff_Ste2_Yck=5.0*10^(-1) 190 koff_Ste2Gpa1GDP_Ste4Ste18=koff_Gpa1GDP_Ste4Ste18/Ste2_Gpa1_Ste4Ste18_coop_factor 191 koff_Ste2Gpa1GTP_Ste4Ste18=GTP_modulating_factor*koff_Gpa1GDP_Ste4Ste18/Ste2_Gpa1_Ste4Ste18_coop_factor 192 koff_Ste4_Ste20= 193 koff_Ste4Ste18_Ste4Ste18Ste5Ste5=Ste4Ste18Ste5_Ste5_coop_factor*koff_Ste4Ste18_Ste5/Ste4Ste18Ste5_Ste4Ste18Ste5_coop_factor 194 koff_Ste4Ste18_Ste5= 195 koff_Ste4Ste18_Ste5Ste5=koff_Ste4Ste18_Ste5/Ste4Ste18Ste5_Ste5_coop_factor 196 koff_Ste4Ste18Ste5_Ste4Ste18Ste5=koff_Ste5_Ste5/Ste4Ste18Ste5_Ste4Ste18Ste5_coop_factor 197 koff_Ste4Ste18Ste5_Ste5=koff_Ste5_Ste5/Ste4Ste18Ste5_Ste5_coop_factor 198 koff_Ste5_Fus3=kon_Ste5_Fus3*Kd_Ste5_Fus3 199 koff_Ste5_Kss1=kon_Ste5_Kss1*Kd_Ste5_Kss1 200 koff_Ste5_Ste11= 201 koff_Ste5_Ste5= 202 koff_Ste5_Ste7= 203 koff_Ste7_MAPK=kon_Ste7_MAPK*Kd_Ste7_MAPK 204 kon_Fus3pT_Dig1=kon_Fus3pTpY_Dig1 205 kon_Fus3pT_Dig2=kon_Fus3pTpY_Dig2 206 kon_Fus3pT_Far1=kon_Fus3pTpY_Far1 207 kon_Fus3pTpY_Dig1= 208 kon_Fus3pTpY_Dig2= 209 kon_Fus3pTpY_Far1= 210 kon_Fus3pY_Dig1=kon_Fus3pTpY_Dig1 211 kon_Fus3pY_Dig2=kon_Fus3pTpY_Dig2 212 kon_Fus3pY_Far1=kon_Fus3pTpY_Far1 213 kon_Gpa1GDP_Ste4Ste18= 214 kon_Gpa1GTP_Ste4Ste18=kon_Gpa1GDP_Ste4Ste18 215 kon_Kss1pT_Dig1=kon_Kss1pTpY_Dig1 216 kon_Kss1pT_Dig2=kon_Kss1pTpY_Dig2 217 kon_Kss1pT_Far1=kon_Kss1pTpY_Far1 218 kon_Kss1pTpY_Dig1=kon_Fus3pTpY_Dig1 219 kon_Kss1pTpY_Dig2=kon_Fus3pTpY_Dig2 220 kon_Kss1pTpY_Far1=kon_Fus3pTpY_Far1 221 kon_Kss1pY_Dig1=kon_Kss1pTpY_Dig1 222 kon_Kss1pY_Dig2=kon_Kss1pTpY_Dig2 223 kon_Kss1pY_Far1=kon_Kss1pTpY_Far1 224 kon_MAPKpT_Sst2=kon_MAPKpTpY_Sst2 225 kon_MAPKpT_Ste11=kon_MAPKpTpY_Ste11 226 kon_MAPKpTpY_Sst2= 227 kon_MAPKpTpY_Ste11= 228 kon_MAPKpY_Sst2=kon_MAPKpTpY_Sst2 229 kon_MAPKpY_Ste11=kon_MAPKpTpY_Ste11 230 kon_Msg5_MAPK= 231 kon_Pheromone_Ste2=koff_Pheromone_Ste2/Kd_Pheromone_Ste2 232 kon_Ptp_MAPK= 233 kon_Ste12_Dig1= 234 kon_Ste12_Dig1PO4=kon_Ste12_Dig1 235 kon_Ste12_Dig2= 236 kon_Ste12_Dig2PO4=kon_Ste12_Dig2 237 kon_Ste12_Fus3= 238 kon_Ste12_Fus3pT=kon_Ste12_Fus3 239 kon_Ste12_Fus3pTpY=kon_Ste12_Fus3 240 kon_Ste12_Fus3pY=kon_Ste12_Fus3 241 kon_Ste12_Kss1= 242 kon_Ste12_Kss1pT=kon_Ste12_Kss1 243 kon_Ste12_Kss1pTpY=kon_Ste12_Kss1 244 kon_Ste12_Kss1pY=kon_Ste12_Kss1 245 kon_Ste12Dig1_Dig2=kon_Ste12_Dig2 246 kon_Ste12Dig1_Dig2PO4=kon_Ste12_Dig2 247 kon_Ste12Dig1_Fus3=kon_Ste12_Fus3 248 kon_Ste12Dig1_Fus3pT=kon_Ste12_Fus3 249 kon_Ste12Dig1_Fus3pTpY=kon_Ste12_Fus3 250 kon_Ste12Dig1_Fus3pY=kon_Ste12_Fus3 251 kon_Ste12Dig1_Kss1=kon_Ste12_Kss1 252 kon_Ste12Dig1_Kss1pT=kon_Ste12_Kss1 253 kon_Ste12Dig1_Kss1pTpY=kon_Ste12_Kss1 254 kon_Ste12Dig1_Kss1pY=kon_Ste12_Kss1 255 kon_Ste12Dig2_Dig1=kon_Ste12_Dig1 256 kon_Ste12Dig2_Dig1PO4=kon_Ste12_Dig1 257 kon_Ste12Fus3_Dig1=kon_Ste12_Dig1 258 kon_Ste12Fus3_Dig1PO4=kon_Ste12_Dig1 259 kon_Ste12Fus3Dig2_Dig1=kon_Ste12_Dig1 260 kon_Ste12Fus3Dig2_Dig1PO4=kon_Ste12_Dig1 261 kon_Ste12Kss1_Dig1=kon_Ste12_Dig1 262 kon_Ste12Kss1_Dig1PO4=kon_Ste12_Dig1 263 kon_Ste12Kss1Dig2_Dig1=kon_Ste12_Dig1 264 kon_Ste12Kss1Dig2_Dig1PO4=kon_Ste12_Dig1 265 kon_Ste2_Gpa1= 266 kon_Ste2_Gpa1Ste4Ste18=kon_Ste2_Gpa1 267 kon_Ste2_Sst2= 268 kon_Ste2_Yck=0.5 269 kon_Ste2Gpa1GDP_Ste4Ste18=kon_Gpa1GDP_Ste4Ste18 270 kon_Ste2Gpa1GTP_Ste4Ste18=kon_Gpa1GDP_Ste4Ste18 271 kon_Ste4_Ste20= 272 kon_Ste4Ste18_Ste4Ste18Ste5Ste5=kon_Ste4Ste18_Ste5 273 kon_Ste4Ste18_Ste5= 274 kon_Ste4Ste18_Ste5Ste5=kon_Ste4Ste18_Ste5 275 kon_Ste4Ste18Ste5_Ste4Ste18Ste5=kon_Ste5_Ste5 276 kon_Ste4Ste18Ste5_Ste5=kon_Ste5_Ste5 277 kon_Ste5_Fus3= 278 kon_Ste5_Kss1=kon_Ste5_Fus3 279 kon_Ste5_Ste11= 280 kon_Ste5_Ste5= 281 kon_Ste5_Ste7= 282 kon_Ste7_MAPK= 283 Kss1_num=5480 284 Kss1_tot_conc=Kss1_num*1e6/(Cell_volume*Avogadros_number) 285 ksynth_Gpa1=Gpa1_tot_conc*kdeg_Gpa1 286 ksynth_Sst2=Sst2_tot_conc*kdeg_Sst2 287 ksynth_Ste11=Ste11_tot_conc*kdeg_Ste11 288 ksynth_Ste12_Dig2= 289 ksynth_Ste12_Far1= 290 ksynth_Ste12_Fus3= 291 ksynth_Ste12_Gpa1= 292 ksynth_Ste12_Msg5= 293 ksynth_Ste12_Ptp= 294 ksynth_Ste12_Sst2= 295 ksynth_Ste12_Ste12= 296 ksynth_Ste12_Ste2= 297 ksynth_Ste2=Ste2_tot_conc*kinternalization_Ste2 298 ksynth_Ste7=Ste7_tot_conc*kdeg_Ste7 299 MAPK_pT_only_Kd_factor=MAPK_pY_only_Kd_factor 300 MAPK_pT_only_PO4_factor=10 301 MAPK_pY_only_Kd_factor=2 302 MAPK_pY_only_PO4_factor=35 303 Msg5_num=538 304 Msg5_tot_conc=Msg5_num*1e6/(Cell_volume*Avogadros_number) 305 Pheromone_tot_conc= 306 Ptp_num=917 307 Ptp_tot_conc=Ptp_num*1e6/(Cell_volume*Avogadros_number) 308 Sst2_num=4000 309 Sst2_tot_conc=Sst2_num*1e6/(Cell_volume*Avogadros_number) 310 Ste11_num=736 311 Ste11_pS_only_PO4_factor= 312 Ste11_tot_conc=Ste11_num*1e6/(Cell_volume*Avogadros_number) 313 Ste12_Dig1_Dig2_coop_factor= 314 Ste12_Dig1_Fus3_coop_factor= 315 Ste12_Dig1_Kss1_coop_factor= 316 Ste12_Dig1_PO4_factor= 317 Ste12_Dig2_PO4_factor= 318 Ste12_Fus3_pT_factor= 319 Ste12_Fus3_pTpY_factor= 320 Ste12_Fus3_pY_factor=Ste12_Fus3_pT_factor 321 Ste12_Kss1_pT_factor= 322 Ste12_Kss1_pTpY_factor= 323 Ste12_Kss1_pY_factor=Ste12_Kss1_pT_factor 324 Ste12_num=1920 325 Ste12_tot_conc=Ste12_num*1e6/(Cell_volume*Avogadros_number) 326 Ste2_Gpa1_Ste4Ste18_coop_factor= 327 Ste2_num=7100 328 Ste2_tot_conc=Ste2_num*1e6/(Cell_volume*Avogadros_number) 329 Ste20_num=259 330 Ste20_tot_conc=Ste20_num*1e6/(Cell_volume*Avogadros_number) 331 Ste4_num=9000 332 Ste4_tot_conc=Ste4_num*1e6/(Cell_volume*Avogadros_number) 333 Ste4Ste18Ste5_Ste4Ste18Ste5_coop_factor= 334 Ste4Ste18Ste5_Ste5_coop_factor= 335 Ste5_num=1900 336 Ste5_tot_conc=Ste5_num*1e6/(Cell_volume*Avogadros_number) 337 Ste50_tot_conc= 338 Ste7_num=672 339 Ste7_pS_only_PO4_factor= 340 Ste7_tot_conc=Ste7_num*1e6/(Cell_volume*Avogadros_number) 341 Tec1_tot= 342 Yck_num=7790 343 Yck_tot_conc=Yck_num*1e6/(Cell_volume*Avogadros_number) end parameters begin molecule types 1 Cell 2 Dig1(Ste12_site,MAPK_site,PO4_site~none~PO4) 3 Dig2(Ste12_site,MAPK_site,PO4_site~none~PO4) 4 Far1(MAPK_site,S87~none~PO4,T306~none~PO4) 5 Fus3(target_site,T180~none~PO4,Y182~none~PO4) 6 Gpa1(Ste2_site,Sst2_site,Ste4_site,nucleotide~GDP~GTP) 7 Kss1(target_site,T183~none~PO4,Y185~none~PO4) 8 Msg5(MAPK_site) 9 Pheromone(Ste2_site) 10 Ptp(MAPK_site) 11 Sst2(Ste2_site,MAPK_site,S539~none~PO4) 12 Ste11(Ste5_site,MAPK_site,S302_S306_T307~none~pS~pSpS~pSpSpT,Feedback_PO4~none~PO4) 13 Ste12(Dig1_site,Dig2_site,MAPK_site) 14 Ste2(Pheromone_site,Gpa1_site,Sst2_site,Yck_site,S338_S339~none~PO4) 15 Ste20(Ste4_site,Ste11_site) 16 Ste4(Gpa1_site,Ste5_site,Ste20_site) 17 Ste5(Ste5_site,Ste4_site,Ste11_site,Ste7_site,MAPK_site) 18 Ste50(Ste11_site) 19 Ste7(Ste5_site,MAPK_site,S359_T363~none~pS~pSpT) 20 Yck(Ste2_site) end molecule types begin seed species 1 Cell Cell_tot_conc 2 Dig1(Ste12_site,MAPK_site,PO4_site~none) Dig1_tot_conc 3 Dig2(Ste12_site,MAPK_site,PO4_site~none) Dig2_tot_conc 4 Far1(MAPK_site,S87~none,T306~none) Far1_tot_conc 5 Fus3(target_site,T180~none,Y182~none) Fus3_tot_conc 6 Gpa1(Ste2_site,Sst2_site,Ste4_site,nucleotide~GDP) Gpa1_tot_conc 7 Kss1(target_site,T183~none,Y185~none) Kss1_tot_conc 8 Msg5(MAPK_site) Msg5_tot_conc 9 Pheromone(Ste2_site) Pheromone_tot_conc 10 Ptp(MAPK_site) Ptp_tot_conc 11 Sst2(Ste2_site,MAPK_site,S539~none) Sst2_tot_conc 12 Ste11(Ste5_site,MAPK_site,S302_S306_T307~none,Feedback_PO4~none) Ste11_tot_conc 13 Ste12(Dig1_site,Dig2_site,MAPK_site) Ste12_tot_conc 14 Ste2(Pheromone_site,Gpa1_site,Sst2_site,Yck_site,S338_S339~none) Ste2_tot_conc 15 Ste20(Ste4_site,Ste11_site) Ste20_tot_conc 16 Ste4(Gpa1_site,Ste5_site,Ste20_site) Ste4_tot_conc 17 Ste5(Ste5_site,Ste4_site,Ste11_site,Ste7_site,MAPK_site) Ste5_tot_conc 18 Ste50(Ste11_site) Ste50_tot_conc 19 Ste7(Ste5_site,MAPK_site,S359_T363~none) Ste7_tot_conc 20 Yck(Ste2_site) Yck_tot_conc end seed species begin reaction rules #Dig1/Dig2/Ste12_phosphorylation 1 Dig1(MAPK_site,PO4_site) + Fus3(target_site,T180~PO4,Y182~none) <-> \ Dig1(MAPK_site!1,PO4_site).Fus3(target_site!1,T180~PO4,Y182~none) \ kon_Fus3pT_Dig1 koff_Fus3pT_Dig1 2 Dig1(MAPK_site,PO4_site) + Fus3(target_site,T180~none,Y182~PO4) <-> \ Dig1(MAPK_site!1,PO4_site).Fus3(target_site!1,T180~none,Y182~PO4) \ kon_Fus3pY_Dig1 koff_Fus3pY_Dig1 3 Dig1(MAPK_site,PO4_site) + Fus3(target_site,T180~PO4,Y182~PO4) <-> \ Dig1(MAPK_site!1,PO4_site).Fus3(target_site!1,T180~PO4,Y182~PO4) \ kon_Fus3pTpY_Dig1 koff_Fus3pTpY_Dig1 4 Dig1(MAPK_site,PO4_site) + Kss1(target_site,T183~PO4,Y185~none) <-> \ Dig1(MAPK_site!1,PO4_site).Kss1(target_site!1,T183~PO4,Y185~none) \ kon_Kss1pT_Dig1 koff_Kss1pT_Dig1 5 Dig1(MAPK_site,PO4_site) + Kss1(target_site,T183~none,Y185~PO4) <-> \ Dig1(MAPK_site!1,PO4_site).Kss1(target_site!1,T183~none,Y185~PO4) \ kon_Kss1pY_Dig1 koff_Kss1pY_Dig1 6 Dig1(MAPK_site,PO4_site) + Kss1(target_site,T183~PO4,Y185~PO4) <-> \ Dig1(MAPK_site!1,PO4_site).Kss1(target_site!1,T183~PO4,Y185~PO4) \ kon_Kss1pTpY_Dig1 koff_Kss1pTpY_Dig1 7 Dig1(MAPK_site!1,PO4_site).Fus3(target_site!1,T180~PO4,Y182~none) -> \ Dig1(MAPK_site,PO4_site~PO4) + Fus3(target_site,T180~PO4,Y182~none) \ kcat_Fus3pT_Dig1_PO4 8 Dig1(MAPK_site!1,PO4_site).Fus3(target_site!1,T180~none,Y182~PO4) -> \ Dig1(MAPK_site,PO4_site~PO4) + Fus3(target_site,T180~none,Y182~PO4) \ kcat_Fus3pY_Dig1_PO4 9 Dig1(MAPK_site!1,PO4_site).Fus3(target_site!1,T180~PO4,Y182~PO4) -> \ Dig1(MAPK_site,PO4_site~PO4) + Fus3(target_site,T180~PO4,Y182~PO4) \ kcat_Fus3pTpY_Dig1_PO4 10 Dig1(MAPK_site!1,PO4_site).Kss1(target_site!1,T183~PO4,Y185~none) -> \ Dig1(MAPK_site,PO4_site~PO4) + Kss1(target_site,T183~PO4,Y185~none) \ kcat_Kss1pT_Dig1_PO4 11 Dig1(MAPK_site!1,PO4_site).Kss1(target_site!1,T183~none,Y185~PO4) -> \ Dig1(MAPK_site,PO4_site~PO4) + Kss1(target_site,T183~none,Y185~PO4) \ kcat_Kss1pY_Dig1_PO4 12 Dig1(MAPK_site!1,PO4_site).Kss1(target_site!1,T183~PO4,Y185~PO4) -> \ Dig1(MAPK_site,PO4_site~PO4) + Kss1(target_site,T183~PO4,Y185~PO4) \ kcat_Kss1pTpY_Dig1_PO4 13 Dig2(MAPK_site,PO4_site) + Fus3(target_site,T180~PO4,Y182~none) <-> \ Dig2(MAPK_site!1,PO4_site).Fus3(target_site!1,T180~PO4,Y182~none) \ kon_Fus3pT_Dig2 koff_Fus3pT_Dig2 14 Dig2(MAPK_site,PO4_site) + Fus3(target_site,T180~none,Y182~PO4) <-> \ Dig2(MAPK_site!1,PO4_site).Fus3(target_site!1,T180~none,Y182~PO4) \ kon_Fus3pY_Dig2 koff_Fus3pY_Dig2 15 Dig2(MAPK_site,PO4_site) + Fus3(target_site,T180~PO4,Y182~PO4) <-> \ Dig2(MAPK_site!1,PO4_site).Fus3(target_site!1,T180~PO4,Y182~PO4) \ kon_Fus3pTpY_Dig2 koff_Fus3pTpY_Dig2 16 Dig2(MAPK_site,PO4_site) + Kss1(target_site,T183~PO4,Y185~none) <-> \ Dig2(MAPK_site!1,PO4_site).Kss1(target_site!1,T183~PO4,Y185~none) \ kon_Kss1pT_Dig2 koff_Kss1pT_Dig2 17 Dig2(MAPK_site,PO4_site) + Kss1(target_site,T183~none,Y185~PO4) <-> \ Dig2(MAPK_site!1,PO4_site).Kss1(target_site!1,T183~none,Y185~PO4) \ kon_Kss1pY_Dig2 koff_Kss1pY_Dig2 18 Dig2(MAPK_site,PO4_site) + Kss1(target_site,T183~PO4,Y185~PO4) <-> \ Dig2(MAPK_site!1,PO4_site).Kss1(target_site!1,T183~PO4,Y185~PO4) \ kon_Kss1pTpY_Dig2 koff_Kss1pTpY_Dig2 19 Dig2(MAPK_site!1,PO4_site).Fus3(target_site!1,T180~PO4,Y182~none) -> \ Dig2(MAPK_site,PO4_site~PO4) + Fus3(target_site,T180~PO4,Y182~none) \ kcat_Fus3pT_Dig2_PO4 20 Dig2(MAPK_site!1,PO4_site).Fus3(target_site!1,T180~none,Y182~PO4) -> \ Dig2(MAPK_site,PO4_site~PO4) + Fus3(target_site,T180~none,Y182~PO4) \ kcat_Fus3pY_Dig2_PO4 21 Dig2(MAPK_site!1,PO4_site).Fus3(target_site!1,T180~PO4,Y182~PO4) -> \ Dig2(MAPK_site,PO4_site~PO4) + Fus3(target_site,T180~PO4,Y182~PO4) \ kcat_Fus3pTpY_Dig2_PO4 22 Dig2(MAPK_site!1,PO4_site).Kss1(target_site!1,T183~PO4,Y185~none) -> \ Dig2(MAPK_site,PO4_site~PO4) + Kss1(target_site,T183~PO4,Y185~none) \ kcat_Kss1pT_Dig2_PO4 23 Dig2(MAPK_site!1,PO4_site).Kss1(target_site!1,T183~none,Y185~PO4) -> \ Dig2(MAPK_site,PO4_site~PO4) + Kss1(target_site,T183~none,Y185~PO4) \ kcat_Kss1pY_Dig2_PO4 24 Dig2(MAPK_site!1,PO4_site).Kss1(target_site!1,T183~PO4,Y185~PO4) -> \ Dig2(MAPK_site,PO4_site~PO4) + Kss1(target_site,T183~PO4,Y185~PO4) \ kcat_Kss1pTpY_Dig2_PO4 #Dig1/Dig2/Ste12/Tec1_interactions 25 Ste12(Dig1_site,Dig2_site,MAPK_site) + Dig1(Ste12_site,PO4_site~none) <-> \ Ste12(Dig1_site!1,Dig2_site,MAPK_site).Dig1(Ste12_site!1,PO4_site~none) \ kon_Ste12_Dig1 koff_Ste12_Dig1 26 Ste12(Dig1_site,Dig2_site,MAPK_site) + Dig1(Ste12_site,PO4_site~PO4) <-> \ Ste12(Dig1_site!1,Dig2_site,MAPK_site).Dig1(Ste12_site!1,PO4_site~PO4) \ kon_Ste12_Dig1PO4 koff_Ste12_Dig1PO4 27 Ste12(Dig1_site,Dig2_site!+,MAPK_site) + Dig1(Ste12_site,PO4_site~none) <-> \ Ste12(Dig1_site!1,Dig2_site!+,MAPK_site).Dig1(Ste12_site!1,PO4_site~none) \ kon_Ste12Dig2_Dig1 koff_Ste12Dig2_Dig1 28 Ste12(Dig1_site,Dig2_site!+,MAPK_site) + Dig1(Ste12_site,PO4_site~PO4) <-> \ Ste12(Dig1_site!1,Dig2_site!+,MAPK_site).Dig1(Ste12_site!1,PO4_site~PO4) \ kon_Ste12Dig2_Dig1PO4 koff_Ste12Dig2_Dig1PO4 29 Ste12(Dig1_site,Dig2_site,MAPK_site!2).Kss1(target_site!2) + Dig1(Ste12_site,PO4_site~none) <-> \ Ste12(Dig1_site!1,Dig2_site,MAPK_site!2).Kss1(target_site!2).Dig1(Ste12_site!1,PO4_site~none) \ kon_Ste12Kss1_Dig1 koff_Ste12Kss1_Dig1 30 Ste12(Dig1_site,Dig2_site,MAPK_site!2).Kss1(target_site!2) + Dig1(Ste12_site,PO4_site~PO4) <-> \ Ste12(Dig1_site!1,Dig2_site,MAPK_site!2).Kss1(target_site!2).Dig1(Ste12_site!1,PO4_site~PO4) \ kon_Ste12Kss1_Dig1PO4 koff_Ste12Kss1_Dig1PO4 31 Ste12(Dig1_site,Dig2_site!+,MAPK_site!2).Kss1(target_site!2) + Dig1(Ste12_site,PO4_site~none) <-> \ Ste12(Dig1_site!1,Dig2_site!+,MAPK_site!2).Kss1(target_site!2).Dig1(Ste12_site!1,PO4_site~none) \ kon_Ste12Kss1Dig2_Dig1 koff_Ste12Kss1Dig2_Dig1 32 Ste12(Dig1_site,Dig2_site!+,MAPK_site!2).Kss1(target_site!2) + Dig1(Ste12_site,PO4_site~PO4) <-> \ Ste12(Dig1_site!1,Dig2_site!+,MAPK_site!2).Kss1(target_site!2).Dig1(Ste12_site!1,PO4_site~PO4) \ kon_Ste12Kss1Dig2_Dig1PO4 koff_Ste12Kss1Dig2_Dig1PO4 33 Ste12(Dig1_site,Dig2_site,MAPK_site!2).Fus3(target_site!2) + Dig1(Ste12_site,PO4_site~none) <-> \ Ste12(Dig1_site!1,Dig2_site,MAPK_site!2).Fus3(target_site!2).Dig1(Ste12_site!1,PO4_site~none) \ kon_Ste12Fus3_Dig1 koff_Ste12Fus3_Dig1 34 Ste12(Dig1_site,Dig2_site,MAPK_site!2).Fus3(target_site!2) + Dig1(Ste12_site,PO4_site~PO4) <-> \ Ste12(Dig1_site!1,Dig2_site,MAPK_site!2).Fus3(target_site!2).Dig1(Ste12_site!1,PO4_site~PO4) \ kon_Ste12Fus3_Dig1PO4 koff_Ste12Fus3_Dig1PO4 35 Ste12(Dig1_site,Dig2_site!+,MAPK_site!2).Fus3(target_site!2) + Dig1(Ste12_site,PO4_site~none) <-> \ Ste12(Dig1_site!1,Dig2_site!+,MAPK_site!2).Fus3(target_site!2).Dig1(Ste12_site!1,PO4_site~none) \ kon_Ste12Fus3Dig2_Dig1 koff_Ste12Fus3Dig2_Dig1 36 Ste12(Dig1_site,Dig2_site!+,MAPK_site!2).Fus3(target_site!2) + Dig1(Ste12_site,PO4_site~PO4) <-> \ Ste12(Dig1_site!1,Dig2_site!+,MAPK_site!2).Fus3(target_site!2).Dig1(Ste12_site!1,PO4_site~PO4) \ kon_Ste12Fus3Dig2_Dig1PO4 koff_Ste12Fus3Dig2_Dig1PO4 37 Ste12(Dig1_site,Dig2_site) + Dig2(Ste12_site,PO4_site~none) <-> \ Ste12(Dig1_site,Dig2_site!1).Dig2(Ste12_site!1,PO4_site~none) \ kon_Ste12_Dig2 koff_Ste12_Dig2 38 Ste12(Dig1_site,Dig2_site) + Dig2(Ste12_site,PO4_site~PO4) <-> \ Ste12(Dig1_site,Dig2_site!1).Dig2(Ste12_site!1,PO4_site~PO4) \ kon_Ste12_Dig2PO4 koff_Ste12_Dig2PO4 39 Ste12(Dig1_site!+,Dig2_site) + Dig2(Ste12_site,PO4_site~none) <-> \ Ste12(Dig1_site!+,Dig2_site!1).Dig2(Ste12_site!1,PO4_site~none) \ kon_Ste12Dig1_Dig2 koff_Ste12Dig1_Dig2 40 Ste12(Dig1_site!+,Dig2_site) + Dig2(Ste12_site,PO4_site~PO4) <-> \ Ste12(Dig1_site!+,Dig2_site!1).Dig2(Ste12_site!1,PO4_site~PO4) \ kon_Ste12Dig1_Dig2PO4 koff_Ste12Dig1_Dig2PO4 41 Ste12(Dig1_site,MAPK_site) + Kss1(target_site,T183~none,Y185~none) <-> \ Ste12(Dig1_site,MAPK_site).Kss1(target_site!1,T183~none,Y185~none) \ kon_Ste12_Kss1 koff_Ste12_Kss1 42 Ste12(Dig1_site,MAPK_site) + Kss1(target_site,T183~PO4,Y185~none) <-> \ Ste12(Dig1_site,MAPK_site).Kss1(target_site!1,T183~PO4,Y185~none) \ kon_Ste12_Kss1pT koff_Ste12_Kss1pT 43 Ste12(Dig1_site,MAPK_site) + Kss1(target_site,T183~none,Y185~PO4) <-> \ Ste12(Dig1_site,MAPK_site).Kss1(target_site!1,T183~none,Y185~PO4) \ kon_Ste12_Kss1pY koff_Ste12_Kss1pY 44 Ste12(Dig1_site,MAPK_site) + Kss1(target_site,T183~PO4,Y185~PO4) <-> \ Ste12(Dig1_site,MAPK_site).Kss1(target_site!1,T183~PO4,Y185~PO4) \ kon_Ste12_Kss1pTpY koff_Ste12_Kss1pTpY 45 Ste12(Dig1_site!+,MAPK_site) + Kss1(target_site,T183~none,Y185~none) <-> \ Ste12(Dig1_site!+,MAPK_site).Kss1(target_site!1,T183~none,Y185~none) \ kon_Ste12Dig1_Kss1 koff_Ste12Dig1_Kss1 46 Ste12(Dig1_site!+,MAPK_site) + Kss1(target_site,T183~PO4,Y185~none) <-> \ Ste12(Dig1_site!+,MAPK_site).Kss1(target_site!1,T183~PO4,Y185~none) \ kon_Ste12Dig1_Kss1pT koff_Ste12Dig1_Kss1pT 47 Ste12(Dig1_site!+,MAPK_site) + Kss1(target_site,T183~none,Y185~PO4) <-> \ Ste12(Dig1_site!+,MAPK_site).Kss1(target_site!1,T183~none,Y185~PO4) \ kon_Ste12Dig1_Kss1pY koff_Ste12Dig1_Kss1pY 48 Ste12(Dig1_site!+,MAPK_site) + Kss1(target_site,T183~PO4,Y185~PO4) <-> \ Ste12(Dig1_site!+,MAPK_site).Kss1(target_site!1,T183~PO4,Y185~PO4) \ kon_Ste12Dig1_Kss1pTpY koff_Ste12Dig1_Kss1pTpY 49 Ste12(Dig1_site,MAPK_site) + Fus3(target_site,T180~none,Y182~none) <-> \ Ste12(Dig1_site,MAPK_site).Fus3(target_site!1,T180~none,Y182~none) \ kon_Ste12_Fus3 koff_Ste12_Fus3 50 Ste12(Dig1_site,MAPK_site) + Fus3(target_site,T180~PO4,Y182~none) <-> \ Ste12(Dig1_site,MAPK_site).Fus3(target_site!1,T180~PO4,Y182~none) \ kon_Ste12_Fus3pT koff_Ste12_Fus3pT 51 Ste12(Dig1_site,MAPK_site) + Fus3(target_site,T180~none,Y182~PO4) <-> \ Ste12(Dig1_site,MAPK_site).Fus3(target_site!1,T180~none,Y182~PO4) \ kon_Ste12_Fus3pY koff_Ste12_Fus3pY 52 Ste12(Dig1_site,MAPK_site) + Fus3(target_site,T180~PO4,Y182~PO4) <-> \ Ste12(Dig1_site,MAPK_site).Fus3(target_site!1,T180~PO4,Y182~PO4) \ kon_Ste12_Fus3pTpY koff_Ste12_Fus3pTpY 53 Ste12(Dig1_site!+,MAPK_site) + Fus3(target_site,T180~none,Y182~none) <-> \ Ste12(Dig1_site!+,MAPK_site).Fus3(target_site!1,T180~none,Y182~none) \ kon_Ste12Dig1_Fus3 koff_Ste12Dig1_Fus3 54 Ste12(Dig1_site!+,MAPK_site) + Fus3(target_site,T180~PO4,Y182~none) <-> \ Ste12(Dig1_site!+,MAPK_site).Fus3(target_site!1,T180~PO4,Y182~none) \ kon_Ste12Dig1_Fus3pT koff_Ste12Dig1_Fus3pT 55 Ste12(Dig1_site!+,MAPK_site) + Fus3(target_site,T180~none,Y182~PO4) <-> \ Ste12(Dig1_site!+,MAPK_site).Fus3(target_site!1,T180~none,Y182~PO4) \ kon_Ste12Dig1_Fus3pY koff_Ste12Dig1_Fus3pY 56 Ste12(Dig1_site!+,MAPK_site) + Fus3(target_site,T180~PO4,Y182~PO4) <-> \ Ste12(Dig1_site!+,MAPK_site).Fus3(target_site!1,T180~PO4,Y182~PO4) \ kon_Ste12Dig1_Fus3pTpY koff_Ste12Dig1_Fus3pTpY #Far1/MAPK_interactions 57 Far1(MAPK_site,T306~none) + Fus3(target_site,T180~PO4,Y182~none) <-> \ Far1(MAPK_site!1,T306~none).Fus3(target_site!1,T180~PO4,Y182~none) \ kon_Fus3pT_Far1 koff_Fus3pT_Far1 58 Far1(MAPK_site,T306~none) + Fus3(target_site,T180~none,Y182~PO4) <-> \ Far1(MAPK_site!1,T306~none).Fus3(target_site!1,T180~none,Y182~PO4) \ kon_Fus3pY_Far1 koff_Fus3pY_Far1 59 Far1(MAPK_site,T306~none) + Fus3(target_site,T180~PO4,Y182~PO4) <-> \ Far1(MAPK_site!1,T306~none).Fus3(target_site!1,T180~PO4,Y182~PO4) \ kon_Fus3pTpY_Far1 koff_Fus3pTpY_Far1 60 Far1(MAPK_site!1,T306~none).Fus3(target_site!1,T180~PO4,Y182~none) -> \ Far1(MAPK_site,T306~PO4) + Fus3(target_site,T180~PO4,Y182~none) \ kcat_Fus3pT_Far1_PO4 61 Far1(MAPK_site!1,T306~none).Fus3(target_site!1,T180~none,Y182~PO4) -> \ Far1(MAPK_site,T306~PO4) + Fus3(target_site,T180~none,Y182~PO4) \ kcat_Fus3pY_Far1_PO4 62 Far1(MAPK_site!1,T306~none).Fus3(target_site!1,T180~PO4,Y182~PO4) -> \ Far1(MAPK_site,T306~PO4) + Fus3(target_site,T180~PO4,Y182~PO4) \ kcat_Fus3pTpY_Far1_PO4 63 Far1(MAPK_site,T306~none) + Kss1(target_site,T183~PO4,Y185~none) <-> \ Far1(MAPK_site!1,T306~none).Kss1(target_site!1,T183~PO4,Y185~none) \ kon_Kss1pT_Far1 koff_Kss1pT_Far1 64 Far1(MAPK_site,T306~none) + Kss1(target_site,T183~none,Y185~PO4) <-> \ Far1(MAPK_site!1,T306~none).Kss1(target_site!1,T183~none,Y185~PO4) \ kon_Kss1pY_Far1 koff_Kss1pY_Far1 65 Far1(MAPK_site,T306~none) + Kss1(target_site,T183~PO4,Y185~PO4) <-> \ Far1(MAPK_site!1,T306~none).Kss1(target_site!1,T183~PO4,Y185~PO4) \ kon_Kss1pTpY_Far1 koff_Kss1pTpY_Far1 66 Far1(MAPK_site!1,T306~none).Kss1(target_site!1,T183~PO4,Y185~none) -> \ Far1(MAPK_site,T306~PO4) + Kss1(target_site,T183~PO4,Y185~none) \ kcat_Kss1pT_Far1_PO4 67 Far1(MAPK_site!1,T306~none).Kss1(target_site!1,T183~none,Y185~PO4) -> \ Far1(MAPK_site,T306~PO4) + Kss1(target_site,T183~none,Y185~PO4) \ kcat_Kss1pY_Far1_PO4 68 Far1(MAPK_site!1,T306~none).Kss1(target_site!1,T183~PO4,Y185~PO4) -> \ Far1(MAPK_site,T306~PO4) + Kss1(target_site,T183~PO4,Y185~PO4) \ kcat_Kss1pTpY_Far1_PO4 #Fus3/Gpa1/Ste4_interactions #G_protein_nucleotide_hydrolysis/exchange 69 Gpa1(Ste2_site,Ste4_site,nucleotide~GDP) -> \ Gpa1(Ste2_site,Ste4_site,nucleotide~GTP) \ kcat_Gpa1GDP_GTP 70 Ste2(Pheromone_site,Gpa1_site!2).Gpa1(Ste2_site!2,Ste4_site,nucleotide~GDP) -> \ Ste2(Pheromone_site,Gpa1_site!2).Gpa1(Ste2_site!2,Ste4_site,nucleotide~GTP) \ kcat_Gpa1GDP_GTP 71 Ste2(Pheromone_site!+,Gpa1_site!2).Gpa1(Ste2_site!2,Ste4_site,nucleotide~GDP) -> \ Ste2(Pheromone_site!+,Gpa1_site!2).Gpa1(Ste2_site!2,Ste4_site,nucleotide~GTP) \ kcat_PheromoneSte2Gpa1GDP_GTP 72 Gpa1(Ste2_site,Ste4_site!2,nucleotide~GDP).Ste4(Gpa1_site!2) -> \ Gpa1(Ste2_site,Ste4_site!2,nucleotide~GTP).Ste4(Gpa1_site!2) \ kcat_Gpa1GDPSte4Ste18_GTP 73 Ste2(Pheromone_site,Gpa1_site!2).Gpa1(Ste2_site!2,Ste4_site!+,nucleotide~GDP) -> \ Ste2(Pheromone_site,Gpa1_site!2).Gpa1(Ste2_site!2,Ste4_site!+,nucleotide~GTP) \ kcat_Gpa1GDPSte4Ste18_GTP 74 Ste2(Pheromone_site!+,Gpa1_site!2).Gpa1(Ste2_site!2,Ste4_site!+,nucleotide~GDP) -> \ Ste2(Pheromone_site!+,Gpa1_site!2).Gpa1(Ste2_site!2,Ste4_site!+,nucleotide~GTP) \ kcat_PheromoneSte2Gpa1GDPSte4Ste18_GTP 75 Gpa1(Ste2_site,nucleotide~GTP) -> \ Gpa1(Ste2_site,nucleotide~GDP) \ kcat_Gpa1GTP_GDP 76 Ste2(Gpa1_site!2,Sst2_site).Gpa1(Ste2_site!2,nucleotide~GTP) -> \ Ste2(Gpa1_site!2,Sst2_site).Gpa1(Ste2_site!2,nucleotide~GDP) \ kcat_Gpa1GTP_GDP 77 Ste2(Gpa1_site!2,Sst2_site!+).Gpa1(Ste2_site!2,nucleotide~GTP) -> \ Ste2(Gpa1_site!2,Sst2_site!+).Gpa1(Ste2_site!2,nucleotide~GDP) \ kcat_Sst2Gpa1GTP_GDP #Gpa1_synthesis/degradation 78 Gpa1 + Cell -> \ Cell \ kdeg_Gpa1 DeleteMolecules 79 Cell -> \ Cell + Gpa1(Ste2_site,Sst2_site,Ste4_site,nucleotide~GTP) \ ksynth_Gpa1 #MAPK_phosphorylation_cascade 80 Ste20(Ste4_site!2).Ste4(Ste5_site!3,Ste20_site!2).Ste5(Ste4_site!3,Ste11_site!4).Ste11(Ste5_site!4,S302_S306_T307~none) -> \ Ste20(Ste4_site!2).Ste4(Ste5_site!3,Ste20_site!2).Ste5(Ste4_site!3,Ste11_site!4).Ste11(Ste5_site!4,S302_S306_T307~pS) \ kcat_Ste20Ste4Ste18Ste5Ste11_pS 81 Ste20(Ste4_site!2).Ste4(Ste5_site!3,Ste20_site!2).Ste5(Ste4_site!3,Ste11_site!4).Ste11(Ste5_site!4,S302_S306_T307~pS) -> \ Ste20(Ste4_site!2).Ste4(Ste5_site!3,Ste20_site!2).Ste5(Ste4_site!3,Ste11_site!4).Ste11(Ste5_site!4,S302_S306_T307~pSpS) \ kcat_Ste20Ste4Ste18Ste5Ste11pS_pS 82 Ste20(Ste4_site!2).Ste4(Ste5_site!3,Ste20_site!2).Ste5(Ste4_site!3,Ste11_site!4).Ste11(Ste5_site!4,S302_S306_T307~pSpS) -> \ Ste20(Ste4_site!2).Ste4(Ste5_site!3,Ste20_site!2).Ste5(Ste4_site!3,Ste11_site!4).Ste11(Ste5_site!4,S302_S306_T307~pSpSpT) \ kcat_Ste20Ste4Ste18Ste5Ste11pSpS_pT 83 Ste11(Ste5_site!2,S302_S306_T307~pS).Ste5(Ste11_site!2,Ste5_site!3).Ste5(Ste5_site!3,Ste7_site!4).Ste7(Ste5_site!4,S359_T363~none) -> \ Ste11(Ste5_site!2,S302_S306_T307~pS).Ste5(Ste11_site!2,Ste5_site!3).Ste5(Ste5_site!3,Ste7_site!4).Ste7(Ste5_site!4,S359_T363~pS) \ kcat_Ste11pSSte5Ste5Ste7_pS 84 Ste11(Ste5_site!2,S302_S306_T307~pS).Ste5(Ste11_site!2,Ste5_site!3).Ste5(Ste5_site!3,Ste7_site!4).Ste7(Ste5_site!4,S359_T363~pS) -> \ Ste11(Ste5_site!2,S302_S306_T307~pS).Ste5(Ste11_site!2,Ste5_site!3).Ste5(Ste5_site!3,Ste7_site!4).Ste7(Ste5_site!4,S359_T363~pSpT) \ kcat_Ste11pSSte5Ste5Ste7pS_pT 85 Ste11(Ste5_site!2,S302_S306_T307~pSpS).Ste5(Ste11_site!2,Ste5_site!3).Ste5(Ste5_site!3,Ste7_site!4).Ste7(Ste5_site!4,S359_T363~none) -> \ Ste11(Ste5_site!2,S302_S306_T307~pSpS).Ste5(Ste11_site!2,Ste5_site!3).Ste5(Ste5_site!3,Ste7_site!4).Ste7(Ste5_site!4,S359_T363~pS) \ kcat_Ste11pSpSSte5Ste5Ste7_pS 86 Ste11(Ste5_site!2,S302_S306_T307~pSpS).Ste5(Ste11_site!2,Ste5_site!3).Ste5(Ste5_site!3,Ste7_site!4).Ste7(Ste5_site!4,S359_T363~pS) -> \ Ste11(Ste5_site!2,S302_S306_T307~pSpS).Ste5(Ste11_site!2,Ste5_site!3).Ste5(Ste5_site!3,Ste7_site!4).Ste7(Ste5_site!4,S359_T363~pSpT) \ kcat_Ste11pSpSSte5Ste5Ste7pS_pT 87 Ste11(Ste5_site!2,S302_S306_T307~pSpSpT).Ste5(Ste11_site!2,Ste5_site!3).Ste5(Ste5_site!3,Ste7_site!4).Ste7(Ste5_site!4,S359_T363~none) -> \ Ste11(Ste5_site!2,S302_S306_T307~pSpSpT).Ste5(Ste11_site!2,Ste5_site!3).Ste5(Ste5_site!3,Ste7_site!4).Ste7(Ste5_site!4,S359_T363~pS) \ kcat_Ste11pSpSpTSte5Ste5Ste7_pS 88 Ste11(Ste5_site!2,S302_S306_T307~pSpSpT).Ste5(Ste11_site!2,Ste5_site!3).Ste5(Ste5_site!3,Ste7_site!4).Ste7(Ste5_site!4,S359_T363~pS) -> \ Ste11(Ste5_site!2,S302_S306_T307~pSpSpT).Ste5(Ste11_site!2,Ste5_site!3).Ste5(Ste5_site!3,Ste7_site!4).Ste7(Ste5_site!4,S359_T363~pSpT) \ kcat_Ste11pSpSpTSte5Ste5Ste7pS_pT 89 Ste7(Ste5_site!2,MAPK_site,S359_T363~pS).Ste5(Ste7_site!2,MAPK_site!3).Fus3(target_site!3,T180~none,Y182~none) -> \ Ste7(Ste5_site!2,MAPK_site,S359_T363~pS).Ste5(Ste7_site!2,MAPK_site!3).Fus3(target_site!3,T180~none,Y182~PO4) \ kcat_Ste5Ste7pSFus3_pY 90 Ste7(Ste5_site!2,MAPK_site,S359_T363~pS).Ste5(Ste7_site!2,MAPK_site!3).Fus3(target_site!3,T180~none,Y182~PO4) -> \ Ste7(Ste5_site!2,MAPK_site,S359_T363~pS).Ste5(Ste7_site!2,MAPK_site!3).Fus3(target_site!3,T180~PO4,Y182~PO4) \ kcat_Ste5Ste7pSFus3pY_pT 91 Ste7(Ste5_site!2,MAPK_site,S359_T363~pS).Ste5(Ste7_site!2,MAPK_site!3).Fus3(target_site!3,T180~none,Y182~none) -> \ Ste7(Ste5_site!2,MAPK_site,S359_T363~pS).Ste5(Ste7_site!2,MAPK_site!3).Fus3(target_site!3,T180~PO4,Y182~none) \ kcat_Ste5Ste7pSFus3_pT 92 Ste7(Ste5_site!2,MAPK_site,S359_T363~pS).Ste5(Ste7_site!2,MAPK_site!3).Fus3(target_site!3,T180~PO4,Y182~none) -> \ Ste7(Ste5_site!2,MAPK_site,S359_T363~pS).Ste5(Ste7_site!2,MAPK_site!3).Fus3(target_site!3,T180~PO4,Y182~PO4) \ kcat_Ste5Ste7pSFus3pT_pY 93 Ste7(Ste5_site!2,MAPK_site,S359_T363~pSpT).Ste5(Ste7_site!2,MAPK_site!3).Fus3(target_site!3,T180~none,Y182~none) -> \ Ste7(Ste5_site!2,MAPK_site,S359_T363~pSpT).Ste5(Ste7_site!2,MAPK_site!3).Fus3(target_site!3,T180~none,Y182~PO4) \ kcat_Ste5Ste7pSpTFus3_pY 94 Ste7(Ste5_site!2,MAPK_site,S359_T363~pSpT).Ste5(Ste7_site!2,MAPK_site!3).Fus3(target_site!3,T180~none,Y182~PO4) -> \ Ste7(Ste5_site!2,MAPK_site,S359_T363~pSpT).Ste5(Ste7_site!2,MAPK_site!3).Fus3(target_site!3,T180~PO4,Y182~PO4) \ kcat_Ste5Ste7pSpTFus3pY_pT 95 Ste7(Ste5_site!2,MAPK_site,S359_T363~pSpT).Ste5(Ste7_site!2,MAPK_site!3).Fus3(target_site!3,T180~none,Y182~none) -> \ Ste7(Ste5_site!2,MAPK_site,S359_T363~pSpT).Ste5(Ste7_site!2,MAPK_site!3).Fus3(target_site!3,T180~PO4,Y182~none) \ kcat_Ste5Ste7pSpTFus3_pT 96 Ste7(Ste5_site!2,MAPK_site,S359_T363~pSpT).Ste5(Ste7_site!2,MAPK_site!3).Fus3(target_site!3,T180~PO4,Y182~none) -> \ Ste7(Ste5_site!2,MAPK_site,S359_T363~pSpT).Ste5(Ste7_site!2,MAPK_site!3).Fus3(target_site!3,T180~PO4,Y182~PO4) \ kcat_Ste5Ste7pSpTFus3pT_pY 97 Ste7(MAPK_site!2,Ste5_site,S359_T363~pS).Kss1(target_site!2,T183~none,Y185~none) -> \ Ste7(MAPK_site!2,Ste5_site,S359_T363~pS).Kss1(target_site!2,T183~none,Y185~PO4) \ kcat_Ste7pSKss1_pY 98 Ste7(MAPK_site,Ste5_site!2,S359_T363~pS).Ste5(Ste7_site!2,MAPK_site!3).Kss1(target_site!3,T183~none,Y185~none) -> \ Ste7(MAPK_site,Ste5_site!2,S359_T363~pS).Ste5(Ste7_site!2,MAPK_site!3).Kss1(target_site!3,T183~none,Y185~PO4) \ kcat_Ste7pSKss1_pY 99 Ste7(MAPK_site!2,Ste5_site,S359_T363~pS).Kss1(target_site!2,T183~none,Y185~PO4) -> \ Ste7(MAPK_site!2,Ste5_site,S359_T363~pS).Kss1(target_site!2,T183~PO4,Y185~PO4) \ kcat_Ste7pSKss1pY_pT 100 Ste7(MAPK_site,Ste5_site!2,S359_T363~pS).Ste5(Ste7_site!2,MAPK_site!3).Kss1(target_site!3,T183~none,Y185~PO4) -> \ Ste7(MAPK_site,Ste5_site!2,S359_T363~pS).Ste5(Ste7_site!2,MAPK_site!3).Kss1(target_site!3,T183~PO4,Y185~PO4) \ kcat_Ste7pSKss1pY_pT 101 Ste7(MAPK_site!2,Ste5_site,S359_T363~pS).Kss1(target_site!2,T183~none,Y185~none) -> \ Ste7(MAPK_site!2,Ste5_site,S359_T363~pS).Kss1(target_site!2,T183~PO4,Y185~none) \ kcat_Ste7pSKss1_pT 102 Ste7(MAPK_site,Ste5_site!2,S359_T363~pS).Ste5(Ste7_site!2,MAPK_site!3).Kss1(target_site!3,T183~none,Y185~none) -> \ Ste7(MAPK_site,Ste5_site!2,S359_T363~pS).Ste5(Ste7_site!2,MAPK_site!3).Kss1(target_site!3,T183~PO4,Y185~none) \ kcat_Ste7pSKss1_pT 103 Ste7(MAPK_site!2,Ste5_site,S359_T363~pS).Kss1(target_site!2,T183~PO4,Y185~none) -> \ Ste7(MAPK_site!2,Ste5_site,S359_T363~pS).Kss1(target_site!2,T183~PO4,Y185~PO4) \ kcat_Ste7pSKss1pT_pY 104 Ste7(MAPK_site,Ste5_site!2,S359_T363~pS).Ste5(Ste7_site!2,MAPK_site!3).Kss1(target_site!3,T183~PO4,Y185~none) -> \ Ste7(MAPK_site,Ste5_site!2,S359_T363~pS).Ste5(Ste7_site!2,MAPK_site!3).Kss1(target_site!3,T183~PO4,Y185~PO4) \ kcat_Ste7pSKss1pT_pY 105 Ste7(MAPK_site!2,Ste5_site,S359_T363~pSpT).Kss1(target_site!2,T183~none,Y185~none) -> \ Ste7(MAPK_site!2,Ste5_site,S359_T363~pSpT).Kss1(target_site!2,T183~none,Y185~PO4) \ kcat_Ste7pSpTKss1_pY 106 Ste7(MAPK_site,Ste5_site!2,S359_T363~pSpT).Ste5(Ste7_site!2,MAPK_site!3).Kss1(target_site!3,T183~none,Y185~none) -> \ Ste7(MAPK_site,Ste5_site!2,S359_T363~pSpT).Ste5(Ste7_site!2,MAPK_site!3).Kss1(target_site!3,T183~none,Y185~PO4) \ kcat_Ste7pSpTKss1_pY 107 Ste7(MAPK_site!2,Ste5_site,S359_T363~pS).Kss1(target_site!2,T183~none,Y185~PO4) -> \ Ste7(MAPK_site!2,Ste5_site,S359_T363~pS).Kss1(target_site!2,T183~PO4,Y185~PO4) \ kcat_Ste7pSpTKss1pY_pT 108 Ste7(MAPK_site,Ste5_site!2,S359_T363~pSpT).Ste5(Ste7_site!2,MAPK_site!3).Kss1(target_site!3,T183~none,Y185~PO4) -> \ Ste7(MAPK_site,Ste5_site!2,S359_T363~pSpT).Ste5(Ste7_site!2,MAPK_site!3).Kss1(target_site!3,T183~PO4,Y185~PO4) \ kcat_Ste7pSpTKss1pY_pT 109 Ste7(MAPK_site!2,Ste5_site,S359_T363~pSpT).Kss1(target_site!2,T183~none,Y185~none) -> \ Ste7(MAPK_site!2,Ste5_site,S359_T363~pSpT).Kss1(target_site!2,T183~PO4,Y185~none) \ kcat_Ste7pSpTKss1_pT 110 Ste7(MAPK_site,Ste5_site!2,S359_T363~pSpT).Ste5(Ste7_site!2,MAPK_site!3).Kss1(target_site!3,T183~none,Y185~none) -> \ Ste7(MAPK_site,Ste5_site!2,S359_T363~pSpT).Ste5(Ste7_site!2,MAPK_site!3).Kss1(target_site!3,T183~PO4,Y185~none) \ kcat_Ste7pSpTKss1_pT 111 Ste7(MAPK_site!2,Ste5_site,S359_T363~pS).Kss1(target_site!2,T183~PO4,Y185~none) -> \ Ste7(MAPK_site!2,Ste5_site,S359_T363~pS).Kss1(target_site!2,T183~PO4,Y185~PO4) \ kcat_Ste7pSpTKss1pT_pY 112 Ste7(MAPK_site,Ste5_site!2,S359_T363~pSpT).Ste5(Ste7_site!2,MAPK_site!3).Kss1(target_site!3,T183~PO4,Y185~none) -> \ Ste7(MAPK_site,Ste5_site!2,S359_T363~pSpT).Ste5(Ste7_site!2,MAPK_site!3).Kss1(target_site!3,T183~PO4,Y185~PO4) \ kcat_Ste7pSpTKss1pT_pY #MAPK/phosphatase_interactions 113 Ptp(MAPK_site) + Fus3(target_site,Y182~PO4) <-> \ Ptp(MAPK_site!1).Fus3(target_site!1,Y182~PO4) \ kon_Ptp_MAPK koff_Ptp_MAPK 114 Ptp(MAPK_site) + Kss1(target_site,Y185~PO4) <-> \ Ptp(MAPK_site!1).Kss1(target_site!1,Y185~PO4) \ kon_Ptp_MAPK koff_Ptp_MAPK 115 Ptp(MAPK_site!1).Fus3(target_site!1,Y182~PO4) -> \ Ptp(MAPK_site) + Fus3(target_site,Y182~none) \ kcat_Ptp_MAPK_PO4 116 Ptp(MAPK_site!1).Kss1(target_site!1,Y185~PO4) -> \ Ptp(MAPK_site) + Kss1(target_site,Y185~none) \ kcat_Ptp_MAPK_PO4 117 Msg5(MAPK_site) + Fus3(target_site,T180~PO4,Y182~none) <-> \ Msg5(MAPK_site!1).Fus3(target_site!1,T180~PO4,Y182~none) \ kon_Msg5_MAPK koff_Msg5_MAPK 118 Msg5(MAPK_site) + Fus3(target_site,T180~none,Y182~PO4) <-> \ Msg5(MAPK_site!1).Fus3(target_site!1,T180~none,Y182~PO4) \ kon_Msg5_MAPK koff_Msg5_MAPK 119 Msg5(MAPK_site) + Fus3(target_site,T180~PO4,Y182~PO4) <-> \ Msg5(MAPK_site!1).Fus3(target_site!1,T180~PO4,Y182~PO4) \ kon_Msg5_MAPK koff_Msg5_MAPK 120 Msg5(MAPK_site) + Kss1(target_site,T183~PO4,Y185~none) <-> \ Msg5(MAPK_site!1).Kss1(target_site!1,T183~PO4,Y185~none) \ kon_Msg5_MAPK koff_Msg5_MAPK 121 Msg5(MAPK_site) + Kss1(target_site,T183~none,Y185~PO4) <-> \ Msg5(MAPK_site!1).Kss1(target_site!1,T183~none,Y185~PO4) \ kon_Msg5_MAPK koff_Msg5_MAPK 122 Msg5(MAPK_site) + Kss1(target_site,T183~PO4,Y185~PO4) <-> \ Msg5(MAPK_site!1).Kss1(target_site!1,T183~PO4,Y185~PO4) \ kon_Msg5_MAPK koff_Msg5_MAPK 123 Msg5(MAPK_site!1).Fus3(target_site!1,Y182~PO4) -> \ Msg5(MAPK_site) + Fus3(target_site,Y182~none) \ kcat_Msg5_MAPK_PO4 124 Msg5(MAPK_site!1).Fus3(target_site!1,T180~PO4,Y182~none) -> \ Msg5(MAPK_site) + Fus3(target_site,T180~none,Y182~none) \ kcat_Msg5_MAPK_PO4 125 Msg5(MAPK_site!1).Kss1(target_site!1,Y185~PO4) -> \ Msg5(MAPK_site) + Kss1(target_site,Y185~none) \ kcat_Msg5_MAPK_PO4 126 Msg5(MAPK_site!1).Kss1(target_site!1,T183~PO4,Y185~none) -> \ Msg5(MAPK_site) + Kss1(target_site,T183~none,Y185~none) \ kcat_Msg5_MAPK_PO4 #Non-specific_dephosphorylation 127 Dig1(PO4_site~PO4) -> \ Dig1(PO4_site~none) \ kcat_nonspecific_dephosph 128 Dig2(PO4_site~PO4) -> \ Dig2(PO4_site~none) \ kcat_nonspecific_dephosph 129 Far1(S87~PO4) -> \ Far1(S87~none) \ kcat_nonspecific_dephosph 130 Far1(T306~PO4) -> \ Far1(T306~none) \ kcat_nonspecific_dephosph 131 Fus3(T180~PO4) -> \ Fus3(T180~none) \ kcat_nonspecific_dephosph 132 Fus3(Y182~PO4) -> \ Fus3(Y182~none) \ kcat_nonspecific_dephosph 133 Kss1(T183~PO4) -> \ Kss1(T183~none) \ kcat_nonspecific_dephosph 134 Kss1(Y185~PO4) -> \ Kss1(Y185~none) \ kcat_nonspecific_dephosph 135 Sst2(S539~PO4) -> \ Sst2(S539~none) \ kcat_nonspecific_dephosph 136 Ste2(S338_S339~PO4) -> \ Ste2(S338_S339~none) \ kcat_nonspecific_dephosph 137 Ste7(S359_T363~pSpT) -> \ Ste7(S359_T363~pS) \ kcat_nonspecific_dephosph 138 Ste7(S359_T363~pS) -> \ Ste7(S359_T363~none) \ kcat_nonspecific_dephosph 139 Ste11(S302_S306_T307~pSpSpT) -> \ Ste11(S302_S306_T307~pSpS) \ kcat_nonspecific_dephosph 140 Ste11(S302_S306_T307~pSpS) -> \ Ste11(S302_S306_T307~pS) \ kcat_nonspecific_dephosph 141 Ste11(S302_S306_T307~pS) -> \ Ste11(S302_S306_T307~none) \ kcat_nonspecific_dephosph #Pheromone/Receptor/G_protein_interactions 142 Pheromone(Ste2_site) + Ste2(Pheromone_site) <-> \ Pheromone(Ste2_site!1).Ste2(Pheromone_site!1) \ kon_Pheromone_Ste2 koff_Pheromone_Ste2 143 Ste2(Gpa1_site) + Gpa1(Ste2_site,Ste4_site) <-> \ Ste2(Gpa1_site!1).Gpa1(Ste2_site!1,Ste4_site) \ kon_Ste2_Gpa1 koff_Ste2_Gpa1 144 Ste2(Gpa1_site) + Gpa1(Ste2_site,Ste4_site!+) <-> \ Ste2(Gpa1_site!1).Gpa1(Ste2_site!1,Ste4_site!+) \ kon_Ste2_Gpa1Ste4Ste18 koff_Ste2_Gpa1Ste4Ste18 145 Gpa1(Ste2_site,Ste4_site,nucleotide~GDP) + Ste4(Gpa1_site,Ste5_site,Ste20_site) <-> \ Gpa1(Ste2_site,Ste4_site!1,nucleotide~GDP).Ste4(Gpa1_site!1,Ste5_site,Ste20_site) \ kon_Gpa1GDP_Ste4Ste18 koff_Gpa1GDP_Ste4Ste18 146 Gpa1(Ste2_site,Ste4_site,nucleotide~GTP) + Ste4(Gpa1_site,Ste5_site,Ste20_site) <-> \ Gpa1(Ste2_site,Ste4_site!1,nucleotide~GTP).Ste4(Gpa1_site!1,Ste5_site,Ste20_site) \ kon_Gpa1GTP_Ste4Ste18 koff_Gpa1GTP_Ste4Ste18 147 Gpa1(Ste2_site!+,Ste4_site,nucleotide~GDP) + Ste4(Gpa1_site,Ste5_site,Ste20_site) <-> \ Gpa1(Ste2_site!+,Ste4_site!1,nucleotide~GDP).Ste4(Gpa1_site!1,Ste5_site,Ste20_site) \ kon_Ste2Gpa1GDP_Ste4Ste18 koff_Ste2Gpa1GDP_Ste4Ste18 148 Gpa1(Ste2_site!+,Ste4_site,nucleotide~GTP) + Ste4(Gpa1_site,Ste5_site,Ste20_site) <-> \ Gpa1(Ste2_site!+,Ste4_site!1,nucleotide~GTP).Ste4(Gpa1_site!1,Ste5_site,Ste20_site) \ kon_Ste2Gpa1GTP_Ste4Ste18 koff_Ste2Gpa1GTP_Ste4Ste18 #Protein_dilution/synthesis_due_to_cell_growth 149 {MatchOnce}* + Cell -> \ Cell \ kdilution exclude_reactants(1,Cell) 150 Cell -> \ Cell + Pheromone(Ste2_site) \ kdilutionsynth_pheromone 151 Cell -> \ Cell + Dig1(Ste12_site,MAPK_site,PO4_site~none) \ kdilutionsynth_Dig1 152 Cell -> \ Cell + Dig2(Ste12_site,MAPK_site,PO4_site~none) \ kdilutionsynth_Dig2 153 Cell -> \ Cell + Far1(MAPK_site,S87~none,T306~none) \ kdilutionsynth_Far1 154 Cell -> \ Cell + Fus3(target_site,T180~none,Y182~none) \ kdilutionsynth_Fus3 155 Cell -> \ Cell + Gpa1(Ste2_site,Sst2_site,Ste4_site,nucleotide~GDP) \ kdilutionsynth_Gpa1 156 Cell -> \ Cell + Kss1(target_site,T183~none,Y185~none) \ kdilutionsynth_Kss1 157 Cell -> \ Cell + Msg5(MAPK_site) \ kdilutionsynth_Msg5 158 Cell -> \ Cell + Ptp(MAPK_site) \ kdilutionsynth_Ptp 159 Cell -> \ Cell + Sst2(Ste2_site,MAPK_site,S539~none) \ kdilutionsynth_Sst2 160 Cell -> \ Cell + Ste2(Pheromone_site,Gpa1_site,Sst2_site,Yck_site,S338_S339~none) \ kdilutionsynth_Ste2 161 Cell -> \ Cell + Ste4(Gpa1_site,Ste5_site,Ste20_site) \ kdilutionsynth_Ste4Ste18 162 Cell -> \ Cell + Ste5(Ste5_site,Ste4_site,Ste11_site,Ste7_site,MAPK_site) \ kdilutionsynth_Ste5 163 Cell -> \ Cell + Ste7(Ste5_site,MAPK_site,S359_T363~none) \ kdilutionsynth_Ste7 164 Cell -> \ Cell + Ste11(Ste5_site,MAPK_site,S302_S306_T307~none,Feedback_PO4~none) \ kdilutionsynth_Ste11 165 Cell -> \ Cell + Ste12(Dig1_site,Dig2_site,MAPK_site) \ kdilutionsynth_Ste12 166 Cell -> \ Cell + Ste20(Ste4_site,Ste11_site) \ kdilutionsynth_Ste20 167 Cell -> \ Cell + Yck(Ste2_site) \ kdilutionsynth_Yck #RGS%28Sst2%29/G%CE%B1%28Gpa1%29/Receptor%28Ste2%29_interactions 168 Ste2(Sst2_site,Yck_site,S338_S339~none) + Sst2(Ste2_site,MAPK_site) <-> \ Ste2(Sst2_site!1,Yck_site,S338_S339~none).Sst2(Ste2_site!1,MAPK_site) \ kon_Ste2_Sst2 koff_Ste2_Sst2 #Sst2_synthesis/degradation 169 Fus3(target_site,T180~none,Y182~PO4) + Sst2(Ste2_site,MAPK_site,S539~none) <-> \ Fus3(target_site!1,T180~none,Y182~PO4).Sst2(Ste2_site,MAPK_site!1,S539~none) \ kon_MAPKpY_Sst2 koff_MAPKpY_Sst2 170 Kss1(target_site,T183~none,Y185~PO4) + Sst2(Ste2_site,MAPK_site,S539~none) <-> \ Kss1(target_site!1,T183~none,Y185~PO4).Sst2(Ste2_site,MAPK_site!1,S539~none) \ kon_MAPKpY_Sst2 koff_MAPKpY_Sst2 171 Fus3(target_site,T180~PO4,Y182~none) + Sst2(Ste2_site,MAPK_site,S539~none) <-> \ Fus3(target_site!1,T180~PO4,Y182~none).Sst2(Ste2_site,MAPK_site!1,S539~none) \ kon_MAPKpT_Sst2 koff_MAPKpT_Sst2 172 Kss1(target_site,T183~PO4,Y185~none) + Sst2(Ste2_site,MAPK_site,S539~none) <-> \ Kss1(target_site!1,T183~PO4,Y185~none).Sst2(Ste2_site,MAPK_site!1,S539~none) \ kon_MAPKpT_Sst2 koff_MAPKpT_Sst2 173 Fus3(target_site,T180~PO4,Y182~PO4) + Sst2(Ste2_site,MAPK_site,S539~none) <-> \ Fus3(target_site!1,T180~PO4,Y182~PO4).Sst2(Ste2_site,MAPK_site!1,S539~none) \ kon_MAPKpTpY_Sst2 koff_MAPKpTpY_Sst2 174 Kss1(target_site,T183~PO4,Y185~PO4) + Sst2(Ste2_site,MAPK_site,S539~none) <-> \ Kss1(target_site!1,T183~PO4,Y185~PO4).Sst2(Ste2_site,MAPK_site!1,S539~none) \ kon_MAPKpTpY_Sst2 koff_MAPKpTpY_Sst2 175 Fus3(target_site!1,T180~none,Y182~PO4).Sst2(MAPK_site!1,S539~none) -> \ Fus3(target_site,T180~none,Y182~PO4) + Sst2(MAPK_site,S539~PO4) \ kcat_MAPKpY_Sst2_PO4 176 Kss1(target_site!1,T183~none,Y185~PO4).Sst2(MAPK_site!1,S539~none) -> \ Kss1(target_site,T183~none,Y185~PO4) + Sst2(MAPK_site,S539~PO4) \ kcat_MAPKpY_Sst2_PO4 177 Fus3(target_site!1,T180~PO4,Y182~none).Sst2(MAPK_site!1,S539~none) -> \ Fus3(target_site,T180~PO4,Y182~none) + Sst2(MAPK_site,S539~PO4) \ kcat_MAPKpT_Sst2_PO4 178 Kss1(target_site!1,T183~PO4,Y185~none).Sst2(MAPK_site!1,S539~none) -> \ Kss1(target_site,T183~PO4,Y185~none) + Sst2(MAPK_site,S539~PO4) \ kcat_MAPKpT_Sst2_PO4 179 Fus3(target_site!1,T180~PO4,Y182~PO4).Sst2(MAPK_site,S539~none) -> \ Fus3(target_site,T180~PO4,Y182~PO4) + Sst2(Ste2_site,MAPK_site,S539~PO4) \ kcat_MAPKpTpY_Sst2_PO4 180 Kss1(target_site!1,T183~PO4,Y185~PO4).Sst2(MAPK_site,S539~none) -> \ Kss1(target_site,T183~PO4,Y185~PO4) + Sst2(Ste2_site,MAPK_site,S539~PO4) \ kcat_MAPKpTpY_Sst2_PO4 181 Sst2(S539~none) + Cell -> \ Cell \ kdeg_Sst2 DeleteMolecules 182 Sst2(S539~PO4) + Cell -> \ Cell \ kdeg_Sst2_PO4 DeleteMolecules 183 Cell -> \ Cell + Sst2(Ste2_site,MAPK_site,S539~none) \ ksynth_Sst2 #Ste11_synthesis/degradation 184 Fus3(target_site,T180~none,Y182~PO4) + Ste11(Ste5_site,MAPK_site,Feedback_PO4~none) <-> \ Fus3(target_site!1,T180~none,Y182~PO4).Ste11(Ste5_site,MAPK_site!1,Feedback_PO4~none) \ kon_MAPKpY_Ste11 koff_MAPKpY_Ste11 185 Kss1(target_site,T183~none,Y185~PO4) + Ste11(Ste5_site,MAPK_site,Feedback_PO4~none) <-> \ Kss1(target_site!1,T183~none,Y185~PO4).Ste11(Ste5_site,MAPK_site!1,Feedback_PO4~none) \ kon_MAPKpY_Ste11 koff_MAPKpY_Ste11 186 Fus3(target_site,T180~PO4,Y182~none) + Ste11(Ste5_site,MAPK_site,Feedback_PO4~none) <-> \ Fus3(target_site!1,T180~PO4,Y182~none).Ste11(Ste5_site,MAPK_site!1,Feedback_PO4~none) \ kon_MAPKpT_Ste11 koff_MAPKpT_Ste11 187 Kss1(target_site,T183~PO4,Y185~none) + Ste11(Ste5_site,MAPK_site,Feedback_PO4~none) <-> \ Kss1(target_site!1,T183~PO4,Y185~none).Ste11(Ste5_site,MAPK_site!1,Feedback_PO4~none) \ kon_MAPKpT_Ste11 koff_MAPKpT_Ste11 188 Fus3(target_site,T180~PO4,Y182~PO4) + Ste11(Ste5_site,MAPK_site,Feedback_PO4~none) <-> \ Fus3(target_site!1,T180~PO4,Y182~PO4).Ste11(Ste5_site,MAPK_site!1,Feedback_PO4~none) \ kon_MAPKpTpY_Ste11 koff_MAPKpTpY_Ste11 189 Kss1(target_site,T183~PO4,Y185~PO4) + Ste11(Ste5_site,MAPK_site,Feedback_PO4~none) <-> \ Kss1(target_site!1,T183~PO4,Y185~PO4).Ste11(Ste5_site,MAPK_site!1,Feedback_PO4~none) \ kon_MAPKpTpY_Ste11 koff_MAPKpTpY_Ste11 190 Fus3(target_site!1,T180~none,Y182~PO4).Ste11(Ste5_site,MAPK_site!1,Feedback_PO4~none) -> \ Fus3(target_site,T180~none,Y182~PO4) + Ste11(Ste5_site,MAPK_site,Feedback_PO4~PO4) \ kcat_MAPKpY_Ste11_PO4 191 Kss1(target_site!1,T183~none,Y185~PO4).Ste11(Ste5_site,MAPK_site!1,Feedback_PO4~none) -> \ Kss1(target_site,T183~none,Y185~PO4) + Ste11(Ste5_site,MAPK_site,Feedback_PO4~PO4) \ kcat_MAPKpY_Ste11_PO4 192 Fus3(target_site!1,T180~PO4,Y182~none).Ste11(Ste5_site,MAPK_site!1,Feedback_PO4~none) -> \ Fus3(target_site,T180~PO4,Y182~none) + Ste11(Ste5_site,MAPK_site,Feedback_PO4~PO4) \ kcat_MAPKpT_Ste11_PO4 193 Kss1(target_site!1,T183~PO4,Y185~none).Ste11(Ste5_site,MAPK_site!1,Feedback_PO4~none) -> \ Kss1(target_site,T183~PO4,Y185~none) + Ste11(Ste5_site,MAPK_site,Feedback_PO4~PO4) \ kcat_MAPKpT_Ste11_PO4 194 Fus3(target_site!1,T180~PO4,Y182~PO4).Ste11(Ste5_site,MAPK_site!1,Feedback_PO4~none) -> \ Fus3(target_site,T180~PO4,Y182~PO4) + Ste11(Ste5_site,MAPK_site,Feedback_PO4~PO4) \ kcat_MAPKpTpY_Ste11_PO4 195 Kss1(target_site!1,T183~PO4,Y185~PO4).Ste11(Ste5_site,MAPK_site!1,Feedback_PO4~none) -> \ Kss1(target_site,T183~PO4,Y185~PO4) + Ste11(Ste5_site,MAPK_site,Feedback_PO4~PO4) \ kcat_MAPKpTpY_Ste11_PO4 196 Ste11 + Cell -> \ Cell \ kdeg_Ste11 DeleteMolecules 197 Ste11(Feedback_PO4~PO4) + Cell -> \ Cell \ kdeg_Ste11_PO4 DeleteMolecules 198 Cell -> \ Cell + Ste11(Ste5_site,MAPK_site,S302_S306_T307~none,Feedback_PO4~none) \ ksynth_Ste11 #Ste11/Ste50_interactions #Ste12_mediated_protein_synthesis 199 Ste12(Dig1_site,Dig2_site,MAPK_site) -> \ Ste12(Dig1_site,Dig2_site,MAPK_site) + Dig2(Ste12_site,MAPK_site,PO4_site~none) \ Sat(ksynth_Ste12_Dig2,Km_synth_Ste12_Dig2) 200 Ste12(Dig1_site,Dig2_site,MAPK_site) -> \ Ste12(Dig1_site,Dig2_site,MAPK_site) + Far1(MAPK_site,S87~none,T306~none) \ Sat(ksynth_Ste12_Far1,Km_synth_Ste12_Far1) 201 Ste12(Dig1_site,Dig2_site,MAPK_site) -> \ Ste12(Dig1_site,Dig2_site,MAPK_site) + Fus3(target_site,T180~none,Y182~none) \ Sat(ksynth_Ste12_Fus3,Km_synth_Ste12_Fus3) 202 Ste12(Dig1_site,Dig2_site,MAPK_site) -> \ Ste12(Dig1_site,Dig2_site,MAPK_site) + Gpa1(Ste2_site,Sst2_site,Ste4_site,nucleotide~GDP) \ Sat(ksynth_Ste12_Gpa1,Km_synth_Ste12_Gpa1) 203 Ste12(Dig1_site,Dig2_site,MAPK_site) -> \ Ste12(Dig1_site,Dig2_site,MAPK_site) + Msg5(MAPK_site) \ Sat(ksynth_Ste12_Msg5,Km_synth_Ste12_Msg5) 204 Ste12(Dig1_site,Dig2_site,MAPK_site) -> \ Ste12(Dig1_site,Dig2_site,MAPK_site) + Ptp(MAPK_site) \ Sat(ksynth_Ste12_Ptp,Km_synth_Ste12_Ptp) 205 Ste12(Dig1_site,Dig2_site,MAPK_site) -> \ Ste12(Dig1_site,Dig2_site,MAPK_site) + Sst2(Ste2_site,MAPK_site,S539~none) \ Sat(ksynth_Ste12_Sst2,Km_synth_Ste12_Sst2) 206 Ste12(Dig1_site,Dig2_site,MAPK_site) -> \ Ste12(Dig1_site,Dig2_site,MAPK_site) + Ste2(Pheromone_site,Gpa1_site,Sst2_site,Yck_site,S338_S339~none) \ Sat(ksynth_Ste12_Ste2,Km_synth_Ste12_Ste2) 207 Ste12(Dig1_site,Dig2_site,MAPK_site) -> \ Ste12(Dig1_site,Dig2_site,MAPK_site) + Ste12(Dig1_site,Dig2_site,MAPK_site) \ Sat(ksynth_Ste12_Ste12,Km_synth_Ste12_Ste12) #Ste2_synthesis/endocytosis/degradation 208 Cell -> \ Cell + Ste2(Pheromone_site,Gpa1_site,Sst2_site,Yck_site,S338_S339~none) \ ksynth_Ste2 209 Ste2(Sst2_site,Yck_site,S338_S339~none) + Yck(Ste2_site) <-> \ Ste2(Sst2_site,Yck_site!1,S338_S339~none).Yck(Ste2_site!1) \ kon_Ste2_Yck koff_Ste2_Yck 210 Ste2(Pheromone_site,Yck_site!2,S338_S339~none).Yck(Ste2_site!2) -> \ Ste2(Pheromone_site,Yck_site,S338_S339~PO4) + Yck(Ste2_site) \ kcat_YckSte2_PO4 211 Ste2(Pheromone_site!+,Yck_site!2,S338_S339~none).Yck(Ste2_site!2) -> \ Ste2(Pheromone_site!+,Yck_site,S338_S339~PO4) + Yck(Ste2_site) \ kcat_YckPheromoneSte2_PO4 212 Ste2(S338_S339~PO4) + Cell -> \ Cell \ kdeg_Ste2_PO4 DeleteMolecules #Ste4/Ste18_interaction #Ste4:Ste18/Ste20_interaction 213 Ste4(Gpa1_site,Ste20_site) + Ste20(Ste4_site,Ste11_site) <-> \ Ste4(Gpa1_site,Ste20_site!1).Ste20(Ste4_site!1,Ste11_site) \ kon_Ste4_Ste20 koff_Ste4_Ste20 #Ste4:Ste18/Ste5_interactions_and_Ste5_dimerization/oligomerization 214 Ste5(Ste5_site,Ste4_site) + Ste5(Ste5_site,Ste4_site) <-> \ Ste5(Ste5_site!1,Ste4_site).Ste5(Ste5_site!1,Ste4_site) \ kon_Ste5_Ste5 koff_Ste5_Ste5 215 Ste5(Ste5_site,Ste4_site!+) + Ste5(Ste5_site,Ste4_site) <-> \ Ste5(Ste5_site!1,Ste4_site!+).Ste5(Ste5_site!1,Ste4_site) \ kon_Ste4Ste18Ste5_Ste5 koff_Ste4Ste18Ste5_Ste5 216 Ste5(Ste5_site,Ste4_site!+) + Ste5(Ste5_site,Ste4_site!+) <-> \ Ste5(Ste5_site!1,Ste4_site!+).Ste5(Ste5_site!1,Ste4_site!+) \ kon_Ste4Ste18Ste5_Ste4Ste18Ste5 koff_Ste4Ste18Ste5_Ste4Ste18Ste5 217 Ste4(Gpa1_site,Ste5_site) + Ste5(Ste5_site,Ste4_site) <-> \ Ste4(Gpa1_site,Ste5_site!1).Ste5(Ste5_site,Ste4_site!1) \ kon_Ste4Ste18_Ste5 koff_Ste4Ste18_Ste5 218 Ste4(Gpa1_site,Ste5_site) + Ste5(Ste5_site!2,Ste4_site).Ste5(Ste5_site!2,Ste4_site) <-> \ Ste4(Gpa1_site,Ste5_site!1).Ste5(Ste5_site!2,Ste4_site!1).Ste5(Ste5_site!2,Ste4_site) \ kon_Ste4Ste18_Ste5Ste5 koff_Ste4Ste18_Ste5Ste5 219 Ste4(Gpa1_site,Ste5_site) + Ste5(Ste5_site!2,Ste4_site).Ste5(Ste5_site!2,Ste4_site!+) <-> \ Ste4(Gpa1_site,Ste5_site!1).Ste5(Ste5_site!2,Ste4_site!1).Ste5(Ste5_site!2,Ste4_site!+) \ kon_Ste4Ste18_Ste4Ste18Ste5Ste5 koff_Ste4Ste18_Ste4Ste18Ste5Ste5 #Ste5/MAPK_cascade_interactions 220 Ste5(Ste11_site) + Ste11(Ste5_site,MAPK_site) <-> \ Ste5(Ste11_site!1).Ste11(Ste5_site!1,MAPK_site) \ kon_Ste5_Ste11 koff_Ste5_Ste11 221 Ste5(Ste7_site) + Ste7(Ste5_site,MAPK_site) <-> \ Ste5(Ste7_site!1).Ste7(Ste5_site!1,MAPK_site) \ kon_Ste5_Ste7 koff_Ste5_Ste7 222 Ste5(MAPK_site) + Fus3(target_site) <-> \ Ste5(MAPK_site!1).Fus3(target_site!1) \ kon_Ste5_Fus3 koff_Ste5_Fus3 223 Ste5(MAPK_site) + Kss1(target_site) <-> \ Ste5(MAPK_site!1).Kss1(target_site!1) \ kon_Ste5_Kss1 koff_Ste5_Kss1 #Ste7_synthesis/degradation 224 Ste7 + Cell -> \ Cell \ kdeg_Ste7 DeleteMolecules 225 Ste7(S359_T363~pSpT) + Cell -> \ Cell \ kdeg_Ste7pSpT DeleteMolecules 226 Cell -> \ Cell + Ste7(Ste5_site,MAPK_site,S359_T363~none) \ ksynth_Ste7 #Ste7/MAPK_interactions 227 Ste7(Ste5_site,MAPK_site) + Fus3(target_site) <-> \ Ste7(Ste5_site,MAPK_site!1).Fus3(target_site!1) \ kon_Ste7_MAPK koff_Ste7_MAPK 228 Ste7(Ste5_site,MAPK_site) + Kss1(target_site) <-> \ Ste7(Ste5_site,MAPK_site!1).Kss1(target_site!1) \ kon_Ste7_MAPK koff_Ste7_MAPK #Tec1_synthesis/degradation end reaction rules # Generation of the species and reactions # with pheromone concentration set to zero. generate_network({overwrite=>1}); # Write unequilibrated model to xml (model.xml) writeSBML({prefix=>"model"});